Biofilme auf Medizinprodukten - Klinische Studie/ Mikrobiomstudie - MDC Buhmann

Biofilms on medical devices - clinical study/ microbiome study

Biofilm formation on ureteral stents

The formation of deposits on ureteral stents is an unsolved problem. The deposits are suspected to be of bacterial origin and to have an influence on the course of the disease, the pain sensation and the risk of infection of the patient. In order to be able to investigate these in more detail, an extraction method was first developed.

In a comprehensive clinical study, the deposits were characterized using molecular biological and physical methods. In the process, the composition of the bacteria involved was investigated in a microbiome study.

Publications

Betschart, P., Zumstein, V., Buhmann, M. T., Albrich, W. C., Nolte, O., Güsewell, S., . . . Abt, D. (2019). Influence of biofilms on morbidity associated with short-term indwelling ureteral stents: a prospective observational study. World Journal of Urology, 37(8), 1703-1711.

Buhmann, M. T., Abt, D., Altenried, S., Rupper, P., Betschart, P., Zumstein, V., . . . Ren, Q. (2018). Extraction of biofilms from ureteral stents for quantification and cultivation-dependent and-independent analyses. Frontiers in microbiology, 9, 1470.

Buhmann, M. T., Abt, D., Nolte, O., Neu, T. R., Strempel, S., Albrich, W. C., . . . Maniura-Weber, K. (2019). Encrustations on ureteral stents from patients without urinary tract infection reveal distinct urotypes and a low bacterial load. Microbiome, 7(1), 60.

Betschart, P., Zumstein, V., Buhmann, M. T., Altenried, S., Babst, C., Müllhaupt, G., . . . Abt, D. (2019). Symptoms associated with long-term double-J ureteral stenting and influence of biofilms. Urology, 134, 72-78.

Zumstein, V., Betschart, P., Albrich, W. C., Buhmann, M. T., Ren, Q., Schmid, H.-P., & Abt, D. (2017). Biofilm formation on ureteral stents-Incidence, clinical impact, and prevention. Swiss medical weekly(5).

Zumstein, V., Betschart, P., Buhmann, M. T., Albrich, W. C., Nolte, O., Güsewell, S., . . . Abt, D. (2019). Detection of microbial colonization of the urinary tract of patients prior to secondary ureterorenoscopy is highly variable between different types of assessment: results of a prospective observational study. Biofouling, 35(10), 1083-1092.

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